A saliva test for celiac disease worked almost as well as conventional celiac disease blood tests to screen children for the condition, a group of Italian researchers reported.The researchers, writing in the January 2011 Journal of Pediatric Gastroenterology & Nutrition, screened 4,048 children using saliva samples that were tested for anti-tissue transglutaminase (tTG) immunoglobulin (Ig)A. Of those children, 32 tested positive for tTG-IgA antibodies, while nine had borderline levels.
Thirty-one of the 32 positive children, plus three of the nine borderline children, tested positive in blood tests for celiac disease. Twenty-eight of the children showed villous atrophy in intestinal biopsies, while one had Marsh 1 damage consistent with very early celiac disease. Three of the children started the gluten-free diet without undergoing an endoscopy.
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